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Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis

Abboud, Cely Saad; Rao, Gauri G; Souza, Ercilia E; Zavascki, Alexandre P; Kiffer, Carlos.

Braz. j. infect. dis ; 22(1): 51-54, Jan.-feb. 2018. tab, graf

Article in English | LILACS, SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1039210

ABSTRACT

ABSTRACT A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients. The median time to acute kidney injury was 6.0 (95% CI 3-14) days in the polymyxin-aminoglycoside containing regimen group, against 27.0 (95% CI 6-42) days in the polymyxin with other antimicrobial combinations group (p = 0.03). Polymyxin B with aminoglycosides group progressed faster to any degree of renal dysfunction.

Subject(s)

Humans , Male , Female , Polymyxin B/therapeutic use , Enterobacteriaceae Infections/drug therapy , Kidney/drug effects , Mediastinitis/microbiology , Mediastinitis/drug therapy , Anti-Bacterial Agents/therapeutic use , Microbial Sensitivity Tests , Carbapenems/pharmacology , Retrospective Studies , Treatment Outcome , Statistics, Nonparametric , Risk Assessment , beta-Lactam Resistance/drug effects , Enterobacteriaceae Infections/mortality , Kaplan-Meier Estimate , Acute Kidney Injury/chemically induced , Aminoglycosides/therapeutic use , Mediastinitis/mortality

ABSTRACT

Subject(s)

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